pentobarbital will minimize the extent or influence of imatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unknown.Check Carefully (1)pentobarbital will minimize the extent or impact of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Lack of, or decreased response to tofacit